Why the study?
Do flecainide and quinidine alter arrhythmogenic properties in murine hearts modelling long QT syndrome 3?
Population
Langendorff-perfused wild-type and genetically modified murine hearts modelling long QT syndrome 3
Comparison
Flecainide and quinidine vs Untreated WT and Scn5a+/Δ murine hearts
Design
Preclinical
Authors
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Flecainide may suppress VT in LQT3 models; hypothesis-generating and should not yet inform clinical practice.
Do flecainide and quinidine alter arrhythmogenic properties in murine hearts modelling long QT syndrome 3?
Flecainide, but not quinidine, prevents ventricular tachycardia in a murine model of LQT3 by restoring transmural repolarization gradients.
Stokoe et al. (2006) studied this question.
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