Why the study?
Do flecainide and quinidine prevent atrial arrhythmias in a murine Scn5a+/- model of Brugada syndrome?
Population
10 wild-type (WT) and 10 Scn5a+/- Langendorff-perfused murine hearts (murine Brugada syndrome model)
Comparison
Programmed electrical stimulation, burst pacing… vs Wild-type murine hearts; baseline
Design
Preclinical
Authors
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Hypothesis-generating for critical interval modulation in Brugada atrial arrhythmias; leaves open clinical translation pending human studies.
Do flecainide and quinidine prevent atrial arrhythmias in a murine Scn5a+/- model of Brugada syndrome?
This study demonstrates a clear relationship between critical interval and atrial arrhythmic tendency, showing that flecainide and quinidine prevent atrial arrhythmias in a murine Brugada syndrome model by increasing atrial effective refractory periods.
Dautova et al. (2010) studied this question.
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