Key result
Young Scn5a(+/-) mice exhibited greater electrogram duration ratios and APD/AERP ratios compared with WT mice, indicating increased atrial arrhythmogenicity that normalizes with age.
Why the study?
Does age affect atrial electrophysiological properties and arrhythmogenicity in Scn5a+/- murine hearts?
Population
Young and aged wild-type and Scn5a+/- murine hearts used to model Brugada syndrome
Comparison
Scn5a+/- mutation and aging vs Wild-type (WT) mice and different age groups
Design
Preclinical
Authors
Loading...
Age attenuates arrhythmogenicity in young Scn5a+/- mice; hypothesis-generating for age effects on atrial risk in human SCN5A carriers.
Does age affect atrial electrophysiological properties and arrhythmogenicity in Scn5a+/- murine hearts?
Young Scn5a+/- mice exhibit increased atrial arrhythmogenicity with maximal effects on conduction and repolarization compared to aged Scn5a+/- mice, suggesting age-dependent electrophysiological alterations in this Brugada syndrome model.
Guzadhur et al. (2012) studied Brugada syndrome model (atrial arrhythmic tendency). Scn5a(+/-) mutation and aging vs. Wild-type (WT) and young mice was evaluated on Atrial action potential initiation, propagation and recovery. Young Scn5a(+/-) mice exhibited greater electrogram duration ratios and APD/AERP ratios compared with WT mice, indicating increased atrial arrhythmogenicity that normalizes with age.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: