Key result
The cardiac-specific L-type calcium current enhancer Bay Y5959 prevented the initiation of sustained ventricular tachycardia in 7 of 14 (50%) canine infarct experiments.
Why the study?
Does enhancing L-type calcium current with Bay Y5959 prevent initiation of sustained ventricular tachycardia in healing canine infarcts?
Population
Healing canine infarcts with reentrant circuits in the epicardial border zone during sustained ventricular…
Design
Preclinical
Authors
Loading...
No immediate clinical implications; leaves open translation of L-type calcium enhancement to human postinfarct VT prevention.
Does enhancing L-type calcium current with Bay Y5959 prevent initiation of sustained ventricular tachycardia in healing canine infarcts?
Enhancing L-type calcium current with Bay Y5959 prevents sustained ventricular tachycardia initiation in a canine infarct model by altering conduction properties.
Cabo et al. (2000) studied Ventricular tachycardia in healing canine infarcts (n=14). Bay Y5959 was evaluated on Prevention of initiation of sustained ventricular tachycardia. The cardiac-specific L-type calcium current enhancer Bay Y5959 prevented the initiation of sustained ventricular tachycardia in 7 of 14 (50%) canine infarct experiments.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: