October 1, 1995Circulation
Triggering of Acute Myocardial Infarction Onset by Episodes of Anger
Key result
Episodes of anger in the 2 hours preceding onset triggered acute myocardial infarction (RR 2.3; 95% CI 1.7-3.2), with regular aspirin users having a significantly lower risk than nonusers.
Why the study?
Do episodes of anger trigger the onset of acute myocardial infarction?
Population
1623 patients (501 women) interviewed an average of 4 days after acute myocardial infarction
Comparison
Episodes of anger in the 2 hours preceding the… vs Expected frequency of anger using self-matched…
Design
Case-control
Authors
Discussion
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Implication
Anger may acutely trigger MI with possible aspirin attenuation; hypothesis-generating, requires prospective confirmation before practice change.
Study Design
Type
Observational (n=1,623)
Structured PICO
Do episodes of anger trigger the onset of acute myocardial infarction?
P
Population
1623 patients (501 women) interviewed an average of 4 days after acute myocardial infarction
I
Intervention
Episodes of anger in the 2 hours preceding the onset of myocardial infarction
C
Comparator
Expected frequency of anger using self-matched control data (case-crossover design)
O
Outcome
Onset of acute myocardial infarctionhard clinical
Main Result
Effect estimate: RR 2.3 (95% CI 1.7 to 3.2)
Episodes of anger significantly increase the short-term risk of triggering an acute myocardial infarction, though regular aspirin use may attenuate this risk.
Cite This Study
Mittleman et al. (1995) conducted an observational in Acute Myocardial Infarction (n=1,623). Episodes of anger vs. Self-matched control periods (expected frequency) was evaluated on Onset of acute myocardial infarction (RR 2.3, 95% CI 1.7 to 3.2). Episodes of anger in the 2 hours preceding onset triggered acute myocardial infarction (RR 2.3; 95% CI 1.7-3.2), with regular aspirin users having a significantly lower risk than nonusers.