May 17, 2004AJP Heart and Circulatory Physiology
Transmembrane action potential heterogeneity in the canine isolated arterially perfused right atrium: effect ofIKrandIKur/Itoblock
Key result
I(Kr) block prolonged repolarization homogeneously, whereas I(Kur)/I(to) block abbreviated action potential duration heterogeneously, leading to a reduction in dispersion of repolarization.
Why the study?
Does IKr block or IKur/Ito block alter transmembrane action potential heterogeneity in canine isolated right atrial preparations?
Population
Canine isolated superfused and arterially perfused right atrial (RA) preparations
Comparison
IKr block with E-4031 and combined block of… vs Baseline conditions
Design
Preclinical
Authors
Discussion
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Implication
May reduce atrial dispersion in canine models; hypothesis-generating for ion channel-targeted antiarrhythmics, pending human validation.
Structured PICO
Does IKr block or IKur/Ito block alter transmembrane action potential heterogeneity in canine isolated right atrial preparations?
P
Population
Canine isolated superfused and arterially perfused right atrial (RA) preparations
I
Intervention
IKr block with E-4031 and combined block of IKur/Ito with low concentrations of 4-aminopyridine
C
Comparator
Baseline conditions
O
Outcome
Regional and transmural differences in characteristics of the transmembrane action potential (TAP)surrogate
Electrical heterogeneities exist within the canine atria, and IKur/Ito block reduces right atrial dispersion of repolarization, highlighting major differences between superfused and arterially perfused preparations.
Cite This Study
Burashnikov et al. (2004) studied Transmembrane action potential heterogeneity. I(Kr) block with E-4031 and I(Kur)/I(to) block with 4-aminopyridine vs. Baseline was evaluated on Regional and transmural differences in characteristics of the transmembrane action potential. I(Kr) block prolonged repolarization homogeneously, whereas I(Kur)/I(to) block abbreviated action potential duration heterogeneously, leading to a reduction in dispersion of repolarization.