December 1, 2001Journal of Cardiovascular Electrophysiology
Cellular Basis for Complex T Waves and Arrhythmic Activity Following Combined IKr and IKs Block
Population
Arterially perfused canine left ventricular wedge preparations
Comparison
Combined I block and I block vs Baseline conditions
Design
Preclinical
Authors
Discussion
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Member takes
Implication
May heighten experimental arrhythmia risk with dual channel block; leaves open human translation and requires clinical validation.
Structured PICO
P
Population
Arterially perfused canine left ventricular wedge preparations
I
Intervention
Combined I(Kr) block (d-sotalol; 100 micromol/L) and I(Ks) block (chromanol 293B; 30 to 60 micromol/L)
C
Comparator
Baseline conditions
O
Outcome
Transmembrane action potentials and transmural ECG characteristics (T wave morphology, QT interval, transmural dispersion of repolarization)surrogate
Combined I(Kr) and I(Ks) block in canine ventricular wedges produces complex T waves, marked repolarization dispersion, and early afterdepolarizations linked to polymorphic ventricular tachycardia.
Cite This Study
Emori et al. (2001) studied this question.