Key result
Free-breathing ferumoxytol-enhanced UTE-MRA matches conventional gadolinium-enhanced MRA for pulmonary vasculature image quality.
Why the study?
To evaluate the feasibility of ferumoxytol-enhanced UTE-MRA for depiction of pulmonary vascular and nonvascular structures.
Does ferumoxytol-enhanced UTE-MRA provide comparable or superior image quality of pulmonary vascular and nonvascular structures compared to gadolinium-enhanced conventional MRA in healthy volunteers?
Observational (n=20)
Does ferumoxytol-enhanced UTE-MRA provide comparable or superior image quality of pulmonary vascular and nonvascular structures compared to gadolinium-enhanced conventional MRA in healthy volunteers?
Absolute Event Rate: 98% vs 97%
p-value: p=0.51
Free-breathing ferumoxytol-enhanced UTE-MRA is a feasible alternative to gadolinium-enhanced conventional MRA for simultaneous assessment of pulmonary vasculature and nonvascular structures.
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Comparable quality supports ferumoxytol UTE-MRA feasibility in volunteers; leaves open validation in patients.
Knobloch et al. (2019) conducted an observational in Healthy volunteers (n=20). Ferumoxytol-enhanced UTE-MRA vs. Gadobenate dimeglumine-enhanced conventional MRA was evaluated on Image quality of the vasculature (good/excellent) (p=0.51). Free-breathing ferumoxytol-enhanced UTE-MRA provided good/excellent image quality of the pulmonary vasculature comparable to gadolinium-enhanced conventional MRA (98% vs 97%; p=0.51).
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