Key result
Reperfusion after acute ischemia induced ventricular fibrillation in 8 of 10 dogs, characterized by organized epicardial activation fronts arising near the ischemic border that increasingly overlapped.
The transition to reperfusion-induced ventricular fibrillation in a canine model involves organized epicardial activation originating near the ischemic border zone, despite a disorganized surface ECG.
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May inform reperfusion VF mechanisms; hypothesis-generating in canine models and leaves open human translation.
Ideker et al. (1981) studied Acute ischemia and reperfusion-induced ventricular fibrillation (n=10). Reperfusion after 15-minute coronary occlusion was evaluated on Induction of ventricular fibrillation and epicardial activation patterns. Reperfusion after acute ischemia induced ventricular fibrillation in 8 of 10 dogs, characterized by organized epicardial activation fronts arising near the ischemic border that increasingly overlapped.
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