Key result
Inflammatory endothelial activation was present in 67% of dilated cardiomyopathy patients compared to 0% of controls, correlating with intramyocardial infiltrates.
Why the study?
Is the expression of cell adhesion molecules increased and correlated with inflammatory infiltrates in endomyocardial biopsies of patients with dilated cardiomyopathy?
Population
152 patients with dilated cardiomyopathy (LVEF <40%) and 14 autopsy controls.
Comparison
Immunohistochemical evaluation of cell adhesion… vs Autopsy controls
Design
Cross-sectional
Authors
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Endothelial activation markers may support biopsy-based detection of inflammation in dilated cardiomyopathy; cross-sectional data leave open diagnostic utility and causality.
Cross-Sectional (n=166)
Is the expression of cell adhesion molecules increased and correlated with inflammatory infiltrates in endomyocardial biopsies of patients with dilated cardiomyopathy?
Absolute Event Rate: 67% vs 0%
Endothelial cell adhesion molecule expression is significantly elevated in dilated cardiomyopathy and correlates with inflammatory infiltrates, suggesting diagnostic utility for inflammatory cardiomyopathy.
Noutsias et al. (1999) conducted a cross-sectional in Dilated cardiomyopathy (n=166). Evaluation of endothelial cell adhesion molecules (CAMs) vs. Autopsy controls was evaluated on Inflammatory endothelial activation (concurrent abundance of >3 CAMs). Inflammatory endothelial activation was present in 67% of dilated cardiomyopathy patients compared to 0% of controls, correlating with intramyocardial infiltrates.
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