Why the study?
Does immunohistochemical analysis of cardiac biopsies from patients with dilated cardiomyopathy show evidence of a chronic inflammatory process compared to patients with other cardiac diseases?
Population
255 patients, comprising 170 patients presenting clinically as dilated cardiomyopathy and 85 control…
Comparison
Immunohistochemical analysis of cardiac biopsies vs Biopsies from control patients with other…
Design
Case-control
Authors
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Suggests chronic myocardial inflammation in DCM; leaves open whether immunomodulation improves outcomes.
Does immunohistochemical analysis of cardiac biopsies from patients with dilated cardiomyopathy show evidence of a chronic inflammatory process compared to patients with other cardiac diseases?
Immunohistochemical analysis reveals that a significant percentage of patients with dilated cardiomyopathy have an active chronic autoimmune process within the myocardium.
Kühl et al. (1996) studied this question.
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