Key result
High myocardial CD3+ T-lymphocyte infiltration (≥24/mm2) was independently associated with a significantly increased risk of cardiac death or LVAD implantation (HR 5.70) compared to low infiltration (<13/mm2) in patients with dilated cardiomyopathy.
Why the study?
Dilated cardiomyopathy associated with inflammation carries a poorer prognosis, but standard diagnostic criteria have not been established.
Does myocardial T-lymphocyte infiltration predict prognosis and left ventricular recovery in patients with dilated cardiomyopathy?
Cohort (n=261)
Yes
Does myocardial T-lymphocyte infiltration predict prognosis and left ventricular recovery in patients with dilated cardiomyopathy?
Hazard Ratio: 5.7 (95% CI 2.08–15.66)
Absolute Event Rate: 36% vs 12%
p-value: p=<0.001
Myocardial T-lymphocyte infiltration assessed via endomyocardial biopsy serves as a significant prognostic marker for poor left ventricular recovery in dilated cardiomyopathy.
T-lymphocyte infiltration may refine DCM risk stratification; leaves open whether biopsy informs therapy.
BACKGROUND: Dilated cardiomyopathy (DCM) associated with inflammation is diagnosed by endomyocardial biopsy; patients with this have a poorer prognosis than patients without inflammation. To date, standard diagnostic criteria have not been established. METHODS AND RESULTS: -High was also associated with poor left ventricular functional and morphological recovery at short-term follow up. CONCLUSIONS: T-lymphocyte infiltration has a significant prognostic impact in DCM and a 3-tiered risk-stratification model could be helpful to refine patient categorization.
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A 2022 study conducted a cohort in Dilated cardiomyopathy (n=261). High myocardial CD3+ T-lymphocyte infiltration (≥24/mm2) vs. Low myocardial CD3+ T-lymphocyte infiltration (<13/mm2) was evaluated on Cardiac death or left ventricular assist device (LVAD) implantation (HR 5.70, 95% CI 2.08-15.66, p=<0.001). High myocardial CD3+ T-lymphocyte infiltration (≥24/mm2) was independently associated with a significantly increased risk of cardiac death or LVAD implantation (HR 5.70) compared to low infiltration (<13/mm2) in patients with dilated cardiomyopathy.
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