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February 13, 2006Archives of Internal Medicine

Adipocytokines and Incident Diabetes Mellitus in Older Adults

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Key result

Plasminogen activator inhibitor 1 was independently associated with increased odds of incident diabetes (OR 1.35; 95% CI 1.01-1.81) after controlling for baseline adiposity and metabolic factors.

Why the study?

Do adipocytokines and adiposity predict incident diabetes mellitus in older adults?

Population

2356 white and black adults aged 70 to 79 years in the Health, Aging, and Body Composition Study who did not…

Design

Cohort

Follow-up

5 years

Authors

AKAlka M. KanayaPreventive CardiologyCFChristina Wassel FyrUniversity of California, San FranciscoEVEric VittinghoffElectrophysiology

Discussion

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Overview

Should not yet inform diabetes risk assessment in older adults; leaves open PAI-1 as a causal mediator.

Key Points

  • This study aims to explore the relationship between adipocytokines, adiposity, and the development of diabetes in older adults.
  • Analyzed 2356 white and black adults aged 70 to 79 years without diabetes at baseline.
  • Measured levels of adipocytokines and regional fat area via computed tomography.
  • Defined new diabetes cases through self-report or fasting plasma glucose levels.
  • 143 participants developed diabetes, with 14.1 cases per 1000 person-years over 5 years.
  • Visceral fat area and body mass index independently predicted incident diabetes risk.
  • Only plasminogen activator inhibitor 1 remained as the adipocytokine associated with increased odds of diabetes after controlling for various factors.

Study Design

Type

Cohort (n=2,356)

Structured PICO

Do adipocytokines and adiposity predict incident diabetes mellitus in older adults?

P
Population
2356 white and black adults aged 70 to 79 years in the Health, Aging, and Body Composition Study who did not have diabetes at baseline.
O
Outcome
Incident diabetes mellitus (defined as a self-reported diagnosis of diabetes or a fasting plasma glucose level of ≥126 mg/dL at the second, fourth, or sixth annual examination)hard clinical

Main Result

Effect estimate: OR 1.35 (95% CI 1.01-1.81)

Plasminogen activator inhibitor 1 is an independent predictor of incident diabetes in older adults, partially explaining the link between adiposity and diabetes risk.

Cite This Study

Kanaya et al. (2006) conducted a cohort in Incident diabetes mellitus (n=2,356). Plasminogen activator inhibitor 1 was evaluated on Incident diabetes mellitus (OR 1.35, 95% CI 1.01-1.81). Plasminogen activator inhibitor 1 was independently associated with increased odds of incident diabetes (OR 1.35; 95% CI 1.01-1.81) after controlling for baseline adiposity and metabolic factors.

synapsesocial.com/papers/6a0f95b44fb650da4ffe477dhttps://doi.org/10.1001/archinte.166.3.350
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