Key result
An adipokine pattern comprising C-reactive protein, monocyte chemoattractant protein-1, and insulin was significantly associated with cardiovascular risk factors including HOMA (B 0.58) in obese women.
Why the study?
Obesity plays an important role in developing cardiovascular diseases and diabetes, potentially via adipose tissue secretion of adipokines and proinflammatory cytokines, but the linkage between adipocytokines, insulin, and cardiovascular disease risk required investigation.
Do specific patterns of adipocytokines and insulin associate with cardiovascular disease risk factors in obese women?
Cross-Sectional (n=360)
Do specific patterns of adipocytokines and insulin associate with cardiovascular disease risk factors in obese women?
A pattern of elevated CRP, MCP-1, and insulin is significantly associated with multiple cardiovascular risk factors in obese women, highlighting the role of inflammation in obesity-related cardiovascular risk.
Objectives : Obesity plays an important role in the development of chronic diseases like cardiovascular diseases and diabetes. The possible underlying mechanism for this connection is that adipose tissue secretes an array of chemical messenger adipokines proinflammatory cytokines (tumor necrosis factor-alpha, interleukin-6, and interleukin-1-beta). This study aimed to investigate the linkage between adipocytokines and insulin with the cardiovascular disease risk, with particular reference to the adipokines galectin-3, plasminogen activator inhibitor-1, interleukin-1-beta, C-reactive protein, and monocyte chemoattractant protein. Result: Two patterns were identified. The first pattern was galectin-3, plasminogen activator inhibitor-1 and interleukin-1-beta and the second one was C-reactive protein, insulin and monocyte chemoattractant protein-1. The second pattern was strongly associated with the higher scores for resting metabolic rate, diastolic blood pressure, homeostasis model insulin resistance index, lipid profile (except low density lipoprotein, total cholesterol), and body composition parameters (except fat free mass index and waist hip ratio), while negatively associated with age and high density lipoprotein level (all p < 0.05). The first pattern was, however, significantly associated with body fat mass, obesity degree percentage, waist circumference, fat mass index, and waist hip ratio (P < 0.05 for all).
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Yarizadeh et al. (2020) conducted a cross-sectional in Obesity and Cardiovascular Disease Risk (n=360). Adipocytokine and insulin patterns was evaluated on Association of adipokine Pattern 2 (CRP, MCP-1, insulin) with HOMA (B 0.58, 95% CI 0.48-0.69, p=<0.001). An adipokine pattern comprising C-reactive protein, monocyte chemoattractant protein-1, and insulin was significantly associated with cardiovascular risk factors including HOMA (B 0.58) in obese women.
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