Key result
An adipokine pattern characterized by high levels of CRP, insulin, and MCP-1 was significantly associated with higher resting metabolic rate, diastolic blood pressure, insulin resistance, and adverse lipid profiles in obese women.
Why the study?
Obesity contributes to the development of chronic diseases like cardiovascular diseases and diabetes through adipose tissue secretion of adipokines and proinflammatory cytokines.
Cross-Sectional (n=360)
Answers are grounded in this paper and cite their sources.
In obese women, a specific adipokine pattern characterized by elevated CRP, insulin, and MCP-1 is significantly associated with multiple cardiovascular risk factors, highlighting a potential inflammatory pathway linking obesity to cardiovascular disease.
Objectives: Obesity plays an important role in the development of chronic diseases like cardiovascular diseases and diabetes. The underlying mechanism of this connection is that adipose tissue secretes an array of chemical messenger adipokines proinflammatory cytokines (tumor necrosis factor-alpha, interleukin-6, interleukin-1- beta).Result: Two patterns were identified. The first pattern was galectin-3, plasminogen activator inhibitor-1 and IL-1β and the second one was C-reactive protein, insulin and monocyte chemoattractant protein-1. The second pattern were strongly associated with the higher scores for resting metabolic rate, diastolic blood pressure, homeostasis model insulin resistance index, lipid profile (except low density lipoprotein, total cholesterol), and body composition parameters (except fat free mass index and waist hip ratio), while negatively associated with age and high density lipoprotein level (all p < 0.05). The first pattern was, however, significantly associated with body fat mass, obesity degree percentage, waist circumference, fat mass index, and waist hip ratio (P < 0.05 for all).
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Yarizadeh et al. (2019) conducted a cross-sectional in Obesity and Cardiovascular Disease Risk Factors (n=360). Adipocytokine patterns (Principal Component Analysis) was evaluated on Association of adipokine patterns with cardiovascular disease risk factors. An adipokine pattern characterized by high levels of CRP, insulin, and MCP-1 was significantly associated with higher resting metabolic rate, diastolic blood pressure, insulin resistance, and adverse lipid profiles in obese women.
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