Key result
Post-Fontan prophylactic antithrombotic therapy is linked to ~6% cerebral infarction incidence and severe bleeding complications.
Observational (n=49)
No
Combination therapy with aspirin and warfarin in post-Fontan patients carries a significant risk of severe bleeding complications even at therapeutic PT-INR levels, highlighting the need for individualized drug selection.
May support caution with combination antithrombotic therapy post-Fontan; leaves open optimal prophylaxis in randomized trials.
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Yuji Tanaka (2015) conducted an observational in Post-Fontan procedure (n=49). Prophylactic anticoagulation (warfarin) and/or antiplatelet therapy (aspirin) was evaluated on Incidence of thrombotic or bleeding complications. Among 49 patients receiving prophylactic anticoagulation and/or antiplatelet therapy after the Fontan procedure, 3 developed cerebral infarctions and several experienced severe bleeding complications.
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