Key result
Acute blood pressure elevation via handgrip or phenylephrine decreased aortic valve area (1.15 vs 1.09 cm2, p=0.02), with the impact depending primarily on changes in transvalvular flow rate.
Why the study?
Does acute blood pressure elevation affect the Doppler echocardiographic evaluation of aortic stenosis severity in patients with AS?
Observational (n=22)
Does acute blood pressure elevation affect the Doppler echocardiographic evaluation of aortic stenosis severity in patients with AS?
Acute blood pressure elevation alters Doppler echocardiographic assessment of aortic stenosis severity primarily through changes in transvalvular flow rate.
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May confound Doppler AS grading during acute hypertension; hypothesis-generating for flow-standardized protocols in assessment.
Little et al. (2006) conducted an observational in Aortic stenosis (n=22). Handgrip exercise or phenylephrine infusion vs. Baseline was evaluated on Indices of AS severity (mean pressure gradient, aortic valve area, valve resistance, percentage left ventricular stroke work loss and the energy loss coefficient). Acute blood pressure elevation via handgrip or phenylephrine decreased aortic valve area (1.15 vs 1.09 cm2, p=0.02), with the impact depending primarily on changes in transvalvular flow rate.
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