Key result
Ischemia induced by 1- to 2-minute LAD or LCx occlusion in dogs profoundly altered left ventricular apex rotation dynamics, causing a paradoxical relaxation pattern during isovolumic relaxation.
Why the study?
Does acute ischemia alter left ventricular apex rotation and untwisting in an open-chest dog model?
Does acute ischemia alter left ventricular apex rotation and untwisting in an open-chest dog model?
Acute ischemia alters the dynamic transmural balance of torsional moments, leading to profound changes in left ventricular apex rotation and a paradoxical relaxation pattern.
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Should not change clinical practice; leaves open whether apex rotation dynamics merit human investigation.
Kroeker et al. (1995) studied Myocardial ischemia (n=16). Snare occlusion of LAD or LCx arteries vs. Control preischemic conditions was evaluated on Left ventricular apex rotation and untwisting dynamics. Ischemia induced by 1- to 2-minute LAD or LCx occlusion in dogs profoundly altered left ventricular apex rotation dynamics, causing a paradoxical relaxation pattern during isovolumic relaxation.
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