What does this research mean for the field?

Left ventricular rotational deformation is dependent on the pattern of electrical activation and contractile state, and regional ischemia can cause remote decreases in rotation due to the complex fiber arrangement of the whole ventricle. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

The research investigates how rotational deformation of the left ventricle apex is affected by various interventions using magnetic resonance tagging in dogs.

May 1, 1994Cardiovascular Research

Rotational deformation of the canine left ventricle measured by magnetic resonance tagging: effects of catecholamines, ischaemia, and pacing

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Population

18 dogs (canine model)

Comparison

Inotropic stimulation with dobutamine… vs Baseline measurements

Design

Preclinical

Authors

MBMaurice BuchalterSt. Francis Medical Center FRFrank RademakersCardiac Imaging JWJames L. WeissUniversity of Southern California

Discussion

Member takes

Implication

These animal findings on LV torsion are hypothesis-generating; leaves open translation to human ischemia assessment or imaging.

Key Points

The research investigates how rotational deformation of the left ventricle apex is affected by various interventions using magnetic resonance tagging in dogs.
18 dogs were imaged at baseline and during various interventions including inotropic stimulation, pacing, and ischaemia.
Torsion was quantified separately for epicardium and endocardium across anterior and posterior walls.
Six dogs underwent each type of intervention.
Mean torsion of the epicardium was lower than that of the endocardium for both anterior and posterior walls (p < 0.05).
Dobutamine significantly increased torsion in both epicardium and endocardium (p < 0.05).
Anterior wall ischaemia reduced anterior wall torsion, while posterior wall ischaemia affected posterior wall torsion only (p < 0.05).

Structured PICO

Population

18 dogs (canine model)

Intervention

Inotropic stimulation with dobutamine, chronotropic stimulation with atrial pacing, anterior wall ischaemia, posterior wall ischaemia, and varying left ventricular activation site (atrioventricular pacing)

Comparator

Baseline measurements

Outcome

Apical rotation of the apex (torsion) of the epicardium and endocardium (anterior and posterior walls)surrogate

Rotational deformation of the left ventricle is dependent on the pattern of left ventricular activation and the contractile state, demonstrating that regional ischemia can affect rotation in remote areas.

Cite This Study

Buchalter et al. (1994) studied this question.

synapsesocial.com/papers/6a1c4812d54006be995fcfbb https://doi.org/10.1093/cvr/28.5.629

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Rotational deformation of the canine left ventricle measured by magnetic resonance tagging: effects of catecholamines, ischaemia, and pacing

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Rotational deformation of the canine left ventricle measured by magnetic resonance tagging: effects of catecholamines, ischaemia, and pacing

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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