Key result
Radiofrequency ablation linked to ~86% higher AF recurrence risk versus cryoablation in overweight or obese patients.
Why the study?
Although AF recurs more frequently after catheter ablation in individuals with high BMI, this association may be influenced by race, prompting investigation in Japanese patients.
Does the type of ablation procedure (cryoablation vs radiofrequency ablation) affect atrial fibrillation recurrence in overweight/obese Japanese patients?
Population
726 consecutive Japanese patients with paroxysmal or persistent AF undergoing catheter ablation
Comparison
BMI ≥25 kg/m2 vs BMI <25 kg/m2 across cryoablation or radiofrequency ablation
Design
Observational cohort study
Authors
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Should not yet change ablation choice in overweight Japanese AF patients; hypothesis-generating and requires randomized confirmation.
Cohort (n=726)
No
Does the type of ablation procedure (cryoablation vs radiofrequency ablation) affect atrial fibrillation recurrence in overweight/obese Japanese patients?
Effect estimate: HR 1.86 (95% CI 1.07-3.23)
Absolute Event Rate: 44.6% vs 18%
p-value: p=0.03
Cryoablation may be superior to radiofrequency ablation for preventing atrial fibrillation recurrence in overweight or obese Japanese patients.
Takami et al. (2022) conducted a cohort in Atrial Fibrillation (n=726). Radiofrequency ablation vs. Cryoablation was evaluated on Atrial fibrillation recurrence in overweight/obese patients (BMI ≥25 kg/m2) (HR 1.86, 95% CI 1.07-3.23, p=0.03). Radiofrequency ablation significantly increased the risk of atrial fibrillation recurrence compared to cryoablation in overweight or obese Japanese patients (adjusted HR 1.86).
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