Key result
Ionophoretic activation of expiratory-firing cells in the cat nucleus ambiguus slowed the heart in 15 of 18 neurones tested, whereas excited inspiratory-firing cells never had this effect.
This preclinical study characterizes two distinct populations of vagal preganglionic motoneurones in the cat nucleus ambiguus, differentiating presumed cardioinhibitory from bronchoconstrictor neurons based on firing patterns and physiological effects.
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Distinguishes cardioinhibitory from other vagal neurons in cats; leaves open translation to human autonomic therapies.
McAllen et al. (1978) studied Basic physiology (vagal preganglionic motoneurones) (n=84). Ionophoresis of excitant amino acids was evaluated on Electrophysiological properties and heart rate response. Ionophoretic activation of expiratory-firing cells in the cat nucleus ambiguus slowed the heart in 15 of 18 neurones tested, whereas excited inspiratory-firing cells never had this effect.
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