Key result
Successful resuscitation from cardiac arrest in pigs resulted in progressive myocardial dysfunction, significantly reducing ejection fraction from 0.41 to 0.20 (p<0.05).
Why the study?
Does electric induction of ventricular fibrillation and subsequent resuscitation cause myocardial dysfunction in domestic pigs?
RCT (n=20)
Randomized
No
Does electric induction of ventricular fibrillation and subsequent resuscitation cause myocardial dysfunction in domestic pigs?
p-value: p=<.05
Successful resuscitation from prolonged cardiac arrest in a porcine model results in significant myocardial dysfunction characterized by impaired contractility and ventricular dilation.
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Progressive myocardial dysfunction follows resuscitation in pigs; leaves open relevance to human post-arrest care.
Gazmuri et al. (1996) conducted an RCT in Cardiac arrest (n=20). Ventricular fibrillation and resuscitation vs. Sham control was evaluated on Ejection fraction (p=<.05). Successful resuscitation from cardiac arrest in pigs resulted in progressive myocardial dysfunction, significantly reducing ejection fraction from 0.41 to 0.20 (p<0.05).
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