Why the study?
Does successful cardiac resuscitation from ventricular fibrillation cause progressive myocardial dysfunction in an isolated rat heart model?
Population
15 mature, mechanically ventilated adult male Sprague-Dawley rats
Comparison
Induction of ventricular fibrillation followed… vs Control animals whose hearts were harvested…
Design
Preclinical, Animals were randomized to each of the three subsets immediately…
Follow-up
Up to 20 minutes post-resuscitation
Authors
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Progressive LV dysfunction follows resuscitation in rat model; leaves open relevance to human post-arrest care.
Does successful cardiac resuscitation from ventricular fibrillation cause progressive myocardial dysfunction in an isolated rat heart model?
Successful cardiac resuscitation is followed by progressive systolic and diastolic myocardial dysfunction in the immediate post-resuscitation period in a rat model.
Tang et al. (1993) studied this question.