Key result
Extract-assembled poliovirus empty capsids and procapsids had an isoelectric point of 6.8 and 75S, whereas self-assembled capsids had a pI of 5.0 and 71S, suggesting a morphopoietic factor.
Population
Poliovirus type 1 14S particles and procapsids isolated from virus-infected HeLa cells
Comparison
Extract-mediated assembly of poliovirus empty… vs Self-assembly of poliovirus empty capsids and in…
Design
Preclinical
Authors
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No immediate clinical implications; leaves open identification of the morphopoietic factor for future antiviral research.
Infected cell extracts possess a morphopoietic factor that influences the final conformation of the poliovirus empty shell during assembly.
Putnak et al. (1981) studied Poliovirus infection. Extract-mediated assembly vs. Self-assembly and procapsids was evaluated on Isoelectric point (pI), sedimentation coefficient, and density of empty capsids. Extract-assembled poliovirus empty capsids and procapsids had an isoelectric point of 6.8 and 75S, whereas self-assembled capsids had a pI of 5.0 and 71S, suggesting a morphopoietic factor.
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