August 1, 1981Journal of VirologyOpen Access

Poliovirus morphogenesis. I. Identification of 80S dissociable particles and evidence for the artifactual production of procapsids

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Population

Cytoplasmic extracts of poliovirus-infected cells

Design

Preclinical

Authors

MMM. E. MarongiuUniversity of Siena APAlessandra PaniInstituto Politécnico Nacional MCMaria Valeria CorriasIstituto Giannina Gaslini

Discussion

Member takes

Implication

Challenges poliovirus morphogenesis models; leaves open whether 80S particles are true in vivo precursors.

Structured PICO

Population

Cytoplasmic extracts of poliovirus-infected cells

Intervention

In vitro manipulation (pH 8.5, 0.1% sodium dodecyl sulfate, temperature increase)

Outcome

Physical properties of 80S sedimenting particles and modalities of procapsid appearance in vitro

The study challenges the current model of poliovirus morphogenesis by demonstrating that 80S procapsids may be artifactually produced in vitro rather than being stable fundamental precursors.

Cite This Study

Marongiu et al. (1981) studied this question.

synapsesocial.com/papers/6a8293db0bb5b6a5f21e0e2c https://doi.org/10.1128/jvi.39.2.341-347.1981

View Full Paper

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Poliovirus morphogenesis. I. Identification of 80S dissociable particles and evidence for the artifactual production of procapsids

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Poliovirus morphogenesis. I. Identification of 80S dissociable particles and evidence for the artifactual production of procapsids

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider