Morphogenesis of Poliovirus II. Demonstration of a New Intermediate, the Proviron
Population
Poliovirus-infected cells
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Elucidates poliovirus assembly pathway; extends prior models but leaves open validation in other systems.
Structured PICO
P
Population
Poliovirus-infected cells
I
Intervention
Pulse-chase experiments and studies employing the virus-specific inhibitor, guanidine
O
Outcome
Identification and characterization of the provirion intermediate in poliovirus morphogenesissurrogate
The study identifies the provirion as a key intermediate in poliovirus morphogenesis, formed by the combination of newly synthesized RNA with the procapsid.
Cite This Study
Fernandez-Tomas et al. (1973) studied this question.