Key result
Fixed-dose ARB and CCB linked to improved adherence and MACE-free survival versus free combinations.
Why the study?
Does a fixed-dose combination of an angiotensin II receptor blocker and a calcium channel blocker improve medication adherence and clinical outcomes compared to free combinations in patients with hypertension?
Cohort (n=5,680)
Does a fixed-dose combination of an angiotensin II receptor blocker and a calcium channel blocker improve medication adherence and clinical outcomes compared to free combinations in patients with hypertension?
Fixed-dose combinations of ARBs and CCBs improve medication adherence and are associated with better cardiovascular outcomes compared to free combinations in hypertensive patients.
May support fixed-dose ARB/CCB use for adherence in hypertension; extends observational data but leaves outcome benefits open to RCTs.
Using the National Health Insurance Research Database of Taiwan, the authors identified 1136 patients taking fixed-dose combination and 4544 patients taking free combinations of an angiotensin II receptor blocker and a dihydropyridine calcium channel blocker from January 2009 to December 2012. At a mean follow-up of 2.1 years, the fixed-dose combination was associated with improved medication adherence and persistence and better survival free from major adverse cardiac events and hospitalization for heart failure compared with the free combination regimens.
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Tung et al. (2017) conducted a cohort in Hypertension (n=5,680). Fixed-dose combination of an angiotensin II receptor blocker and a calcium channel blocker vs. Free combinations of an angiotensin II receptor blocker and a calcium channel blocker was evaluated on Medication adherence, persistence, survival free from major adverse cardiac events, and hospitalization for heart failure. In a cohort of 5680 patients, fixed-dose combination of an ARB and a CCB improved medication adherence and survival free from MACE and heart failure hospitalization compared with free combinations.
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