No clinical study data is present in the provided text, which consists only of journal editorial board information.
Does cardiopulmonary bypass surgery alter platelet volume and count acutely and chronically in patients undergoing CABG or heart valve replacement?
Cardiopulmonary bypass induces acute thrombocytopenia followed by a rebound thrombocytosis and long-term changes in steady-state thrombopoiesis, resulting in higher platelet counts and lower platelet volumes.
Patients undergoing surgery for coronary artery bypass graft or heart valve replacement had their platelet count and mean volume measured pre-operatively, immediately post-operatively and serially for up to 48 days after the surgical procedure. The mean pre-operative platelet count of 1.95 +/- 0.11 X 10(11)/1 (n = 26) fell significantly to 1.35 +/- 0.09 X 10(11)/1 immediately post-operatively (p less than 0.001) (n = 22), without a significant alteration in the mean platelet volume. The average platelet count rose to a maximum of 5.07 +/- 0.66 X 10(11)/1 between days 14 and 17 after surgery while the average mean platelet volume fell from preparative and post-operative values of 7.25 +/- 0.14 and 7.20 +/- 0.14 fl respectively to a minimum of 6.16 +/- 0.16 fl by day 20. Seven patients were followed for 32 days or longer after the operation. By this time they had achieved steady state thrombopoiesis and their average platelet count was 2.44 +/- 0.33 X 10(11)/1, significantly higher than the pre-operative value (p less than 0.05), while their average mean platelet volume was 6.63 +/- 0.21 fl, significantly lower than before surgery (p less than 0.001). The pre-operative values for the platelet volume and counts of these patients were significantly different from a control group of 32 young males, while the chronic post-operative values were not. These long term changes in platelet volume and count may reflect changes in the thrombopoietic control system secondary to the corrective surgery.
Martin et al. (Thu,) reported a other. No clinical study data is present in the provided text, which consists only of journal editorial board information.