Key result
Cardiopulmonary bypass during valve replacement caused an initial profound decrease in platelet count, adhesiveness, and aggregation, followed by a sustained increase after the sixth postoperative day.
Why the study?
Does insertion of cardiac valve prostheses alter platelet adhesiveness and aggregation in patients?
Population
10 patients undergoing insertion of cardiac valve prostheses (open-heart surgery)
Comparison
Insertion of cardiac valve prostheses using… vs Preoperative baseline
Design
Cohort
Follow-up
several days after operation
Authors
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Platelet rebound after valve replacement may raise thromboembolic risk; leaves open whether adjusted antiplatelet regimens improve outcomes in prospective studies.
Observational (n=10)
Does insertion of cardiac valve prostheses alter platelet adhesiveness and aggregation in patients?
Following cardiac valve replacement, a sustained increase in platelet count and aggregation occurs after an initial postoperative drop, which may contribute to thromboembolic complications.
McKenzie et al. (1969) conducted an observational in Insertion of cardiac valve prostheses (n=10). Open-heart surgery with cardiopulmonary bypass vs. Preoperative levels was evaluated on Platelet adhesiveness, aggregation, and count. Cardiopulmonary bypass during valve replacement caused an initial profound decrease in platelet count, adhesiveness, and aggregation, followed by a sustained increase after the sixth postoperative day.
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