Key result
Outpatient diuretic escalation in HFrEF is linked to ~153% more HF hospitalizations but not mortality.
Why the study?
In contemporary US outpatient practice, the degree to which diuretic dosing changes over time and its associations with clinical outcomes and health care resource utilization were unknown.
Does an increase in outpatient diuretic dose associate with clinical outcomes and health care resource utilization in patients with HFrEF?
Cohort (n=3,426)
Yes
Does an increase in outpatient diuretic dose associate with clinical outcomes and health care resource utilization in patients with HFrEF?
Effect estimate: RR 2.53 (95% CI 2.10-3.05)
In outpatients with HFrEF, escalation of diuretic therapy is common and associated with significantly higher rates of HF hospitalizations and resource utilization, but not mortality.
Diuretic escalation signals higher HF hospitalization risk in HFrEF outpatients; leaves open causal contribution versus disease severity marker.
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Khan et al. (2021) conducted a cohort in chronic heart failure with reduced ejection fraction (n=3,426). Diuretic dose increase vs. No increase in diuretic dose was evaluated on Heart failure hospitalizations (RR 2.53, 95% CI 2.10-3.05). Outpatient diuretic dose escalation in heart failure with reduced ejection fraction was associated with increased heart failure hospitalizations (RR 2.53; 95% CI 2.10-3.05) but not mortality.
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