Key result
In rats with congestive heart failure, long-term treatment with ivabradine decreased heart rate by 18% versus untreated controls, improving left ventricular function and stroke volume.
Why the study?
Does ivabradine improve left ventricular function and intrinsic myocardial structure in rats with congestive heart failure?
Does ivabradine improve left ventricular function and intrinsic myocardial structure in rats with congestive heart failure?
In a rat model of heart failure, long-term heart rate reduction with ivabradine improves LV function and induces beneficial structural modifications in the myocardium.
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Extends preclinical HF data; leaves open clinical translation pending human trials.
Mulder et al. (2004) studied Congestive heart failure. Ivabradine vs. Untreated was evaluated on Heart rate, left ventricular function, and intrinsic myocardial structure. In rats with congestive heart failure, long-term treatment with ivabradine decreased heart rate by 18% versus untreated controls, improving left ventricular function and stroke volume.
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