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March 13, 2024American Heart JournalOpen Access

Predicting the risk of 1-year mortality among patients hospitalized for acute heart failure in China

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Why the study?

The authors aimed to develop and validate a model and risk score to predict 1-year mortality risk among patients hospitalized for acute heart failure to guide clinical decision making.

Can a 13-predictor risk model accurately predict 1-year mortality in patients hospitalized for acute heart failure?

Population

4,875 patients hospitalized for AHF in 52 hospitals across 20 provinces in China

Design

Prospective cohort study for model development and validation

Follow-up

1-year

Key result

A 13-variable prediction model for 1-year mortality among patients hospitalized for acute heart failure demonstrated high discrimination (validation C-index 0.761; 95% CI 0.731-0.791).

Authors

LZLihua ZhangWWWei WangXHXiqian Huo

Discussion

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Member takes

Overview

May aid post-discharge risk stratification in acute HF; leaves open external validation and outcome impact before routine use.

Study Design

Type

Cohort (n=4,875)

Multicenter

Yes

Structured PICO

Can a 13-predictor risk model accurately predict 1-year mortality in patients hospitalized for acute heart failure?

P
Population
4,875 patients hospitalized for acute heart failure (AHF) enrolled from 52 hospitals across 20 provinces in China
I
Intervention
A 13-predictor risk model/score (age, COPD, hypertension, SBP, KCCQ-12, ACEi/ARB at discharge, discharge symptom, NT-proBNP, hs-TnT, serum creatine, albumin, BUN, hs-CRP)
O
Outcome
1-year mortality following discharge of index hospitalizationhard clinical

Main Result

Effect estimate: C-index 0.761 (validation) (95% CI 0.731-0.791)

A newly developed 13-predictor risk score accurately predicts 1-year mortality in Chinese patients hospitalized for acute heart failure, providing a useful tool for individual risk stratification.

Cite This Study

Zhang et al. (2024) conducted a cohort in acute heart failure (n=4,875). 13-predictor risk model vs. Existing risk scores was evaluated on 1-year mortality (C-index 0.761 (validation), 95% CI 0.731-0.791). A 13-variable prediction model for 1-year mortality among patients hospitalized for acute heart failure demonstrated high discrimination (validation C-index 0.761; 95% CI 0.731-0.791).

synapsesocial.com/papers/6a0fa2032badbc352afe7570https://doi.org/10.1016/j.ahj.2024.03.005
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