Computational modeling demonstrates that left ventricular relaxation rate significantly impacts regional coronary flow distribution and myocardial work, offering insights into subendocardial ischemia vulnerability.
Altered relaxation rate may disproportionately affect subendocardial perfusion; hypothesis-generating for diastolic-targeted therapies pending in vivo validation.
We present a model of left ventricle perfusion based on an anatomically realistic coronary tree structure that includes its interaction with the systemic circulation. Left ventricular relaxation rate has a significant effect on the regional distribution of coronary flow and myocardial work.
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Namani et al. (2020) studied this question.
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