Key result
Increased coronary perfusion linearly increased transverse stiffness and shifted in-plane stress-strain relations to the left in canine myocardium, effects that were decreased following embolisation.
Why the study?
Does coronary perfusion directly affect myocardial tissue stiffness in an isolated canine heart model?
Population
Isolated, perfused canine interventricular septal preparation
Comparison
Different levels of coronary perfusion and… vs Different perfusion levels and pre- vs…
Design
Preclinical
Authors
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Coronary perfusion effects on stiffness should not alter clinical practice; extends mechanistic insights in animal models but leaves human relevance open.
Does coronary perfusion directly affect myocardial tissue stiffness in an isolated canine heart model?
Myocardial tissue stiffness is directly related to coronary perfusion, primarily driven by the perfusion of capillaries and/or venules.
Resar et al. (1993) studied Myocardial mechanical properties. Different levels of coronary perfusion and embolisation was evaluated on In-plane stress-strain relations and transverse stiffness. Increased coronary perfusion linearly increased transverse stiffness and shifted in-plane stress-strain relations to the left in canine myocardium, effects that were decreased following embolisation.
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