Numerical Evaluation of Myofiber Orientation and Transmural Contractile Strength on Left Ventricular Function
Key result
LV modeling shows reduced contractile strength amplifies altered myofiber orientation effects on stroke volume.
Population
Finite element (FE) model of the left ventricle
Design
Preclinical
Authors
Discussion
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Implication
LV modeling findings warrant integrated assessment of myocardial properties in dysfunction; leaves open human validation for heart failure.
Structured PICO
P
Population
Finite element (FE) model of the left ventricle
I
Intervention
Variations in transmural distributions of myofiber orientation and contractile strength
O
Outcome
Starling relationship and end-systolic (ES) apex twist of the LV (stroke volume)surrogate
Transmural distribution of myocardial contractile strength and its interplay with myofiber orientation significantly impact LV pump function and apex twist, which may be critical in understanding heart failure progression.
Cite This Study
Zhang et al. (2014) studied Left ventricular function. Finite element (FE) model of the left ventricle was evaluated on Starling relationship and end-systolic (ES) apex twist of the LV. Finite element modeling of the left ventricle showed that reductions in transmural contractile strength amplified the effects of altered myofiber orientation, causing greater changes in stroke volume.