Key result
A noninvasive computational approach using finite element models and MRI demonstrated that the midmyocardium produces more contractile force than other transmural layers.
Population
Animal-specific finite element (FE) models
Design
Preclinical
Authors
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Animal data support layer-specific modeling; leaves open human validation before any clinical use.
A noninvasive computational approach combining finite element models with MRI can accurately predict the transmural distribution of myocardial contractility, demonstrating that the midmyocardium produces more contractile force.
Wang et al. (2016) studied Left ventricular contractility (n=4). Noninvasive computational approach (finite element models) was evaluated on Transmural distribution of maximum isometric tension (Tmax) and reference sarcomere length (lR). A noninvasive computational approach using finite element models and MRI demonstrated that the midmyocardium produces more contractile force than other transmural layers.
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