Key result
In dogs with LV remodeling, the subendocardial CP/ATP ratio was significantly lower compared with normal dogs (1.71 vs 2.04, P < .05) and inversely correlated with increases in LV mass and volume.
Population
20 dogs
Comparison
LV remodeling induced by transmyocardial DC shock vs Normal dogs
Design
Preclinical
Follow-up
12.9 +/- 1.3 months
Authors
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Associates impaired energetics with canine LV remodeling; hypothesis-generating and leaves open translation to human HF.
Absolute Event Rate: 1.71% vs 2.04%
p-value: p=<.05
In a canine model, LV remodeling is associated with altered myocardial high-energy phosphate levels, which further deteriorate during pacing-induced tachycardia alongside subendocardial hypoperfusion.
Zhang et al. (1995) studied Left ventricular remodeling (n=20). Left ventricular remodeling secondary to transmyocardial DC shock vs. Normal dogs was evaluated on Subendocardial creatine phosphate (CP)/ATP ratio under basal conditions (p=<.05). In dogs with LV remodeling, the subendocardial CP/ATP ratio was significantly lower compared with normal dogs (1.71 vs 2.04, P < .05) and inversely correlated with increases in LV mass and volume.
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