December 1, 1996AJP Regulatory Integrative and Comparative Physiology
Ventricular remodeling during development and recovery from modified tachycardia-induced cardiomyopathy model
Key result
Increasing RVP rates in dogs reduces EF to 25% and increases LV mass index.
- P<0.05
Why the study?
Characterization of left ventricular function and mass during development and recovery from a modified tachycardia-induced cardiomyopathy model with gradual pacing rate increase was needed.
Population
Dogs subjected to modified tachycardia-induced cardiomyopathy protocol
Comparison
LV function and mass before and after progressive pacing and recovery
Design
Experimental cardiomyopathy model with gradual right ventricular pacing rate increase
Follow-up
38 days pacing plus 4 weeks recovery
Authors
Discussion
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Member takes
Implication
Validates canine pacing cardiomyopathy model; hypothesis-generating for human RV pacing effects on LV remodeling.
PICO
P
Population
Dogs subjected to a modified cardiomyopathy model with gradually increasing right ventricular pacing rates over 38 days, followed by 4 weeks of recovery.
I
Intervention / Comparator
Gradually increasing right ventricular pacing rates vs Normal dogs
O
Primary Outcome
Ejection fraction, p=< 0.05
Main Result
Absolute Event Rate: 25% vs 60%
p-value: p=< 0.05
Cite This Study
Yamamoto et al. (1996) studied Tachycardia-induced cardiomyopathy. Gradually increasing right ventricular pacing rates vs. Normal dogs was evaluated on Ejection fraction (p=< 0.05). Gradually increasing right ventricular pacing rates in dogs reduced ejection fraction (25% vs 60%) and increased LV mass index (5.2 vs 4.3 g/kg) compared to normal dogs (P<0.05).