June 1, 1991Cardiovascular Research
Sequential echocardiographic-Doppler assessment of left ventricular remodelling and mitral regurgitation during evolving experimental heart failure
Population
17 male mongrel dogs, weight 24.9 (SD 3.7) kg
Comparison
Rapid ventricular pacing until severe heart… vs Baseline (control) measurements prior to pacing
Design
Preclinical
Follow-up
Until severe heart failure developed (assessed weekly)
Authors
Discussion
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Member takes
Implication
LV remodeling tracks HF progression in canine pacing model; leaves open human translation and therapeutic targeting.
Structured PICO
P
Population
17 male mongrel dogs, weight 24.9 (SD 3.7) kg
I
Intervention
Rapid ventricular pacing (250 beats/min) until severe heart failure developed
C
Comparator
Baseline (control) measurements prior to pacing
O
Outcome
Nature, magnitude, and time course of left ventricular structural adaptations (including diastolic volume, shape, and wall thickness) and mitral regurgitationsurrogate
In a canine model of pacing-induced heart failure, left ventricular remodeling and dilation directly correlate with the time to severe heart failure, with mitral regurgitation developing secondary to left ventricular cross-sectional area increase.
Cite This Study
Howard et al. (1991) studied this question.