Key result
Volume-overload hypertrophy induced by a systemic arteriovenous fistula resulted in a uniform 20-27% increase in myocardial mass across the left ventricular wall after a mean of 3.6 weeks in dogs.
Population
5 dogs with implanted gold beads in the left ventricular anterior free wall
Comparison
Volume-overload hypertrophy induced by creating… vs Control state at equal end-diastolic pressures
Design
Preclinical
Follow-up
mean 3.6 weeks
Authors
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Does not inform clinical volume-overload management; leaves open human translation of uniform transmural growth.
Volume-overload hypertrophy induces uniform transmural myocardial tissue growth with substantial cross-fiber expansion in a canine model.
Omens et al. (1991) studied Volume-overload hypertrophy (n=5). Systemic arteriovenous fistula (volume overload) vs. Control state (before cardiac enlargement) was evaluated on Transmural variation in tissue growth (myocardial mass increase). Volume-overload hypertrophy induced by a systemic arteriovenous fistula resulted in a uniform 20-27% increase in myocardial mass across the left ventricular wall after a mean of 3.6 weeks in dogs.
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