Risk factors of mortality among heart failure patients in Jordan: the Jordanian Heart Failure Registry (JoHFR)

Background: Heart failure is one of the most common medical burdens facing the healthcare system worldwide. Based on our knowledge, only two heart failure registries have been conducted in the Middle East. Therefore, we decided to conduct this heart failure registry to investigate the follow-up results of patients with both acute and chronic heart failure in Jordan. Methods: This study is a prospective observational multicenter national registry encompassing 21 health institutes in Jordan, comprising university hospitals, private hospitals, and private clinics. The criteria of inclusion were patients visiting the cardiology clinic or inpatients who were admitted due to acute decompensated HF. The primary outcome was 30-day mortality. Results: The total number of enrolled patients in the study was 2128, with a total number of deaths during the follow-up of 204. Multivariate analysis demonstrated that smoking (odds ratio [OR] = 3.214; 1.005-5139), positive family history of premature coronary artery disease (OR = 2.686; 1.504-4.798), insulin (OR = 2.300; 1.356-3.899), hyponatremia at presentation (OR = 7.058; 1.698-29.342) and increased left ventricular diameter (OR = 1.009; 1.002-1.016) were significantly associated with higher odds of mortality. Conclusion: Smoking, positive family history of premature coronary artery disease, insulin use, hyponatremia on presentation, and increased left ventricular diameter were associated with patients' mortality. Physicians should monitor these factors among patients to identify patients who are at higher risk of detrimental outcomes.