What question did this study set out to answer?

This study aims to compare the effectiveness of heparin and dicumarol in inhibiting serum-induced thrombi in dogs.

October 1, 1955Circulation

Studies in Intravascular Coagulation

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Supports convertin as thrombosis trigger with stasis in dogs; leaves open relevance to human venous thrombosis.

This study aims to compare the effectiveness of heparin and dicumarol in inhibiting serum-induced thrombi in dogs.
Canine serum rich in convertin was infused to induce venous thrombosis.
Heparin and dicumarol were administered to assess thrombus inhibition.
The study involved measuring the evolution of thrombi in a canine model.
Heparin significantly inhibited thrombus formation compared to dicumarol (exact metrics not provided).
Serum-induced intravascular thrombi were consistently reduced with heparin treatment, indicating superior efficacy.
The study suggests the crucial role of circulating convertin and its manipulation in preventing thrombosis.

Wessler et al. (1955) studied this question.

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