Why the study?
Does intra-arterial infusion of thrombin and tissue thromboplastin cause vasodilatation in the canine leg?
Does intra-arterial infusion of thrombin and tissue thromboplastin cause vasodilatation in the canine leg?
Thrombin and tissue thromboplastin induce vasodilatation in the canine femoral artery, with distinct responses to heparin inhibition.
Thrombin's dual effects in canine arteries warrant no clinical extrapolation; leaves open human vascular responses to intra-arterial thrombin.
Thrombin was infused into a canine femoral artery. At low concentrations vasodilatation occurred. At high concentrations the vasodilatation was followed by intravascular coagulation. Heparinization of the animal or diisopropylfluorophosphate treatment of the thrombin inhibited both the vasodilating and procoagulant activity. Tissue thromboplastin had similar effects on femoral vascular resistance. Heparinization of the animal inhibited the procoagulant but not the vasodilating activity. In thrombin, but not in tissue thromboplastin, the vasodilating and procoagulant activities are correlated.
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Delin et al. (1967) studied this question.
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