Key result
Mice lacking the TNF p55 receptor had 2.3-fold larger aortic sinus lesions compared to wild-type mice when fed an atherogenic diet (37,123 vs 16,688 microm2, p<0.0004).
Why the study?
Does the absence of TNF receptor p55 protect against atherosclerosis in mice fed an atherogenic diet?
Does the absence of TNF receptor p55 protect against atherosclerosis in mice fed an atherogenic diet?
Effect estimate: 2.3-fold larger
Absolute Event Rate: 37123% vs 16688%
p-value: p=< 0.0004
Contrary to the hypothesis that p55 promotes inflammation, the absence of TNF p55 receptors in mice accelerates atherosclerotic lesion development, likely due to increased scavenger receptor activity.
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TNF p55 deficiency accelerates lesions in atherogenic mice; challenges protective hypothesis and leaves human relevance open.
Schreyer et al. (1996) studied Atherosclerosis. Absence of TNF receptor p55 (p55-null) vs. Wild type was evaluated on Aortic sinus lesion size (microm2) (2.3-fold larger, p=< 0.0004). Mice lacking the TNF p55 receptor had 2.3-fold larger aortic sinus lesions compared to wild-type mice when fed an atherogenic diet (37,123 vs 16,688 microm2, p<0.0004).
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