Key result
Review details PAR differences between mouse and human platelets to improve translational research models.
Why the study?
Animal models of platelet protease-activated receptor physiology rely heavily on genetically modified mouse strains, which provide insight but possess inherent limitations.
Comparison
Platelet protease-activated receptor expression and function in mouse vs human
Design
Review
Authors
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Species differences in platelet PARs warrant caution translating mouse thrombosis models to humans; leaves open refined humanized tools for future research.
This review highlights critical species differences in platelet protease-activated receptors between mice and humans, which is important for translating preclinical thrombosis research.
Renna et al. (2023) conducted a review in Platelet function in hemostasis and thrombosis. Protease-activated receptors (PARs) was evaluated. This review summarizes notable protease-activated receptor expression and functional differences between mouse and human platelets, highlighting tools to study human physiology in mouse models.
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