Population
93 mutants at 59 different positions in the Adeno-associated virus type 2 (AAV2) capsid gene
Design
Preclinical
Authors
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May guide AAV vector engineering; leaves open human translation and safety.
Mutational analysis of the AAV2 capsid gene identified key functional domains for capsid assembly, DNA packaging, and viral entry, providing useful information for designing targeted AAV vectors for gene therapy.
Wu et al. (2000) studied this question.
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