Population
Adeno-associated virus type 2 (AAV2) in eukaryotic cells
Comparison
Mutation of protein sequence motifs on the VP1/2… vs Wild-type AAV2
Design
Preclinical
Authors
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Motif mutations impair AAV2 nuclear transport in models; extends trafficking data but leaves open clinical vector optimization.
Specific protein sequence motifs on the VP1/2 N terminus of AAV2, including YXXQ and PDZ-binding motifs, are essential for intracellular trafficking and nuclear entry.
Popa-Wagner et al. (2012) studied this question.
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