Why the study?
Current tissue-level models of cardiac conduction assume gap-junction conductance is constant, resulting in inaccurate predictions of electrical propagation particularly under pathological low junctional-coupling regimes.
A novel non-Ohmic homogenization model enables accurate, computationally efficient organ-level simulations of cardiac electrical propagation that account for the non-linear voltage-dependent conductance of gap junctions.
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May enable scalable organ-level cardiac conduction modeling; leaves open validation for human arrhythmia applications.
Hurtado et al. (2020) studied this question.
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