Key result
Heptanol blocked peak sodium conductance in canine cardiac Purkinje cells with half block at 1.3 mM, shifting steady-state availability and activation to close off the INa window current.
Why the study?
Does heptanol block sodium current in canine cardiac Purkinje cells?
Population
16 internally perfused voltage-clamped canine cardiac Purkinje cells at reduced Na+
Design
Preclinical
Authors
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Heptanol may confound gap junction studies via off-target INa block in Purkinje cells; leaves open validity of prior uncoupling experiments without Na controls.
Does heptanol block sodium current in canine cardiac Purkinje cells?
Heptanol and octanol block cardiac sodium currents at concentrations used for cellular uncoupling, highlighting important off-target electrophysiological effects in experimental models.
Nelson et al. (1991) studied this question. Heptanol was evaluated on Block of peak sodium conductance (INa). Heptanol blocked peak sodium conductance in canine cardiac Purkinje cells with half block at 1.3 mM, shifting steady-state availability and activation to close off the INa window current.
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