Why the study?
Does a charged lidocaine analogue block sodium current when applied externally to mammalian cardiac Purkinje cells?
Population
Single mammalian cardiac Purkinje cells
Comparison
Charged lidocaine analogue applied from the… vs Charged lidocaine analogue applied from the…
Design
Preclinical
Authors
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No immediate clinical implications for anesthetic use; leaves open cardiac-specific external Na channel binding for targeted research.
Does a charged lidocaine analogue block sodium current when applied externally to mammalian cardiac Purkinje cells?
This study demonstrates that cardiac sodium channels have a second external binding site for local anesthetics, distinguishing them functionally from nerve sodium channels.
Alpert et al. (1989) studied this question.
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